Alfonso González

Academic CV

Phone: (56-2) 354 2710
mail: agonzara@med.puc.cl

Investigation

We are interested in the mechanisms that con­trol vesicular protein trafficking along the exo­cytic and endocytic pathways, which together determine the dynamic composition of the cell surface. We are studying: a) The role of the trans-Golgi network and recycling endosomes in the polarized protein sorting to apical and baso­lateral plasma membrane domains of epithelial cells; b) The role of endocytosis in the control of cell surface expression of different receptors, including the paradigmatic epidermal growth factor receptor (EGFR) crucially involved in tu­morigenesis and cancer therapy. In a different project, in collaboration with rheumatologists we are attempting to identify and characterize cell surface proteins that could be potential tar­gets of pathogenic autoantibodies, and mediate neuropsychiatric symptoms and cognitive de­cline in patients with systemic lupus erythema­tosus, the prototypic autoimmune disease.

Selected References

Author(s) Title Date
Soza A, de la Fuente E., Norambuena A., Henklein P., and González A. Sorting competition with membrane-permeable peptides in intact cells revealed discrimination of transmembrane proteins not only at the trans-golgi network but also at pre-Golgi sta 0
Burgos P., Klattenhoff C., de la Fuente E., Rigotti A., and González A. Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I (SR-BI) in MDCK cells Proc. Natl Acad. Sci. USA 101: 3845-385 0
Salazar G. and González A. Novel mechanism for regulation of EGF receptor endocytosis revealed by protein kinase A inhibition. Mol Biol Cell 13; 1677-1693 (2002) 0
Buvinic, S. , Bravo-Zehnder, M., Boyer, J.L., Huidobro-Toro, J.P. and González, A. “Nucleotide p2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells”. J Cell Sci 120: 4289-4301 (2007). 0
Cancino J., Torrealba, C., Soza, A., Yuseff I., Gravotta D., Henklein P., Rodriguez-Boulan E., and Gonzalez A. “Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes” Mol Biol. Cell 18: 4872-4884 (2007). 0
Matus S., Burgos P.V. Bravo-Zehnder, M., Kraft R., Porras O.H., Farías P., Barros F., Torrealba F., Massardo L., Jacobelli S., González A. “Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis”. J. Exp Med 204: 3221-3234 (2007). 0

 

Academic CV

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