María Paz Marzolo

Academic CV

Phone: (56-2) 354-2614
mail: mmarzolo@bio.puc.cl

Investigation

We are interested in the intracellular traffic and function of certain members of the low-density lipoprotein receptor (LDL-R) family. These recep­tors include the low-density lipoprotein recep­tor-related protein (LRP), megalin and ApoER2, multifunctional regarding the variety of their li­gands. They can bind and mediate endocytosis of apoE and apoB bearing lipoproteins, complexes of proteases and proteinase inhibitors, complex­es of vitamins A, B12 and D with their carrier proteins, extracellular matrix proteins and other proteins such as beta-amyloid precursor protein. We are currently studying their sorting signals, exocytic and endocytic pathways and the cellu­lar machinery involved in their sorting behavior in polarized cells, using epithelial MDCK cells and neurons in primary culture as model sys­tems. We are also studying facets of their func­tions in particular pathophysiological processes.

Selected References

Author(s) Title Date
Brandan E, C. Retamal, C. Cabello-Verrugio & M.P. Marzolo. The low density lipoprotein receptor-related protein, LRP, functions as an endocytic receptor for decorin. J Biol Chem. 281, 31562-31571, (2006). 0
Cuitiño, L, Matute R., Retamal, C., Bu, G., Inestrosa, N.C. and Marzolo M.P. ApoER2 is endocytosed by a clathrin-mediated process involving the adap¬tor protein Dab2 independently of its rafts association. Traffic 6 (9): 820-838 (2005). 0
Erranz B., Miquel J.F., Argraves W.S., Barth J.L., Pimentel F., Marzolo M.P. Mega¬lin and cubilin expression in gallbladder epithelium and regulation by bile acids. J Lipid Res 45: 2185-98 (2004). 0
Marzolo M.P., Yuseff M.I., Retamal C., Donoso M., Ezquer F., Farfán P., Li Y. and Bu G. Differential Distribution of LRP and Megalin, in Polarized Epithelial Cells is Determined by their Cytoplasmic Domains. Traffic 4: 273-288 (2003). 0
Li Y., Marzolo M.P., Kerkhof P.V., Strous G.J., Bu G. The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for LDL recep¬tor-related Protein (LRP). J Biol Chem 275:17187-17194 (2000). 0

 

Academic CV

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